Prostate cancer is most common type of cancer among men in almost all the countries. But now, scientists have revealed that DNA testing could help in predicting which men are at highest risk of deadly prostate cancer.
The team at the Institute of Cancer Research, London, said that soon men could also be offered screening similar to the one offered to women in case of breast cancer. As many as 14 separate mutations, which can greatly increase chances of aggressive prostate cancer, have been revealed by them and these could be regarded as the basis of a test.
Such testing could 'revolutionize' care for men, said Prostate Cancer UK. Every year, over 40,000 men are diagnosed with prostate cancer in the UK. Every patient does not need to have invasive therapy, which can cause severe side-effects.
To find out men who are likely to develop and will need treatment for the most aggressive and deadly form of the cancer is the toughest challenge.
As a part of study, the researchers studied blood samples taken from 191 men with prostate cancer and also from three or more close family members suffering with the same condition.
Each sample was analyzed for risky mutations, which comprised of the BRCA genes. These genes are involved in repairing DNA and are also associated to breast and ovarian cancers. The results reveal that 7% of the men possess one of 14 high-risk mutations. It was also found to spread around the body of men in cases with the aggressive prostate cancer.
One of the researchers, Dr. Zsofia Kote-Jarai, said, "I can see in two to three years offering screening to men with prostate cancer and to men worried about their family history".
The revelation has been published in the British Journal of Cancer. Researchers revealed that the screening is not ready yet. A larger trail is already in progress and involves 2,000 men and will test 192 genes.
Dr. Iain Frame, Director of research at the charity Prostate Cancer UK, said there is an urgent need to find out which men are at risk of developing prostate cancer and mainly its aggressive forms.
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