Canadian researchers revealed that women with genetic mutations that are at risks of developing ovarian cancer should get their ovaries removed by age of 35. On analyzing 5,783 women, they said that there exists five-time higher risk of developing ovarian cancer in women with BRCA1 mutations and they should undergo 'prophylactic oophorectomy' by 35.

The study published in the Journal of Clinical Oncology states that the women with BRCA1 mutations also face four-time increase in risk of premature deaths compared to women who underwent surgery till 35. There are 80% reduced chances of developing risks of ovarian cancer and 77% reduction in causing premature deaths women who had been through oophorectomy.

Undergoing oophorectomy helps in lowering risks of ovarian cancer and mortality rate also triggers menopause, said Dr. Don Dizon, a spokesman for the American Society of Clinical Oncology.

In 2008, about 64% of women with mutations removed their ovaries with 25% and 40% underwent prophylactic mastectomy, said Dr Noah Kauff, director of ovarian cancer screening and prevention at Memorial Sloan Kettering Cancer Center in New York City.

About one in 300 to 800 women with a BRCA1 or BRCA2 mutation should undergo prophylactic ovary removal by age 40 or when childbearing is complete, according to American College of Obstetricians and Gynecologists.

Dr. Steven Narod, of the University of Toronto, said that this research is first which supports for evidence of reduction in overall mortality rate in ovarian and breast cancer patients. About 3.8% risks has also been associated with removal of ovaries in women aged 40 with 14.2% risks in women who underwent surgery in 50's.

The interesting fact is that those women who underwent oophorectomy before the age of 35 did not developed an aggressive cancer. Researchers concluded that if women wait to undergo oophorectomy after age of 40, the risk of ovarian cancer probably increases from 1% to 2%.